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Glycolysis
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How Tumors Survive Without Enough Oxygen
Fast-growing tumors often outgrow their own blood supply, leaving pockets of low oxygen inside them. A protein called HIF-1α lets cancer cells sense that shortage and rewire themselves to survive it.
How Cancer Cells Rewire Their Fuel Supply — and Why Diet Can't Simply Outsmart It
Cancer cells often burn sugar differently than healthy cells do. Here's what that shift means biologically, and why ketogenic diets and fasting remain unproven as cancer treatments despite promising early research.
CD19 CAR-T Therapy Produces Durable Remission in TP53-Mutated, Triple-Refractory Burkitt Lymphoma
A 16-year-old male with TP53-mutated Burkitt lymphoma, initially misdiagnosed and refractory to three chemotherapy regimens, achieved complete metabolic response and remains in remission 30 months after CD19-directed CAR-T cell therapy (axicabtagene ciloleucel).