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TP53
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Why Chemotherapy Stops Working: How Cancer Cells Resist Treatment
Chemotherapy often works well at first, then stops. Here's what research reveals about the overlapping biological mechanisms that let cancer cells survive drugs that once worked.
Why Cancer Cells Refuse to Die: The Biology of Apoptosis
Healthy cells carry a built-in instruction to self-destruct when damaged. Cancer depends on disabling that instruction. Here is how the process works, and how it goes wrong.
Why Lung Cancer Isn't One Disease, and What That Means for Treatment
Lung cancer kills more people worldwide than any other cancer, but it is not a single disease. Its causes, genetic drivers, and treatment options differ enormously from one tumor to the next.
CD19 CAR-T Therapy Produces Durable Remission in TP53-Mutated, Triple-Refractory Burkitt Lymphoma
A 16-year-old male with TP53-mutated Burkitt lymphoma, initially misdiagnosed and refractory to three chemotherapy regimens, achieved complete metabolic response and remains in remission 30 months after CD19-directed CAR-T cell therapy (axicabtagene ciloleucel).
Durable Near-Complete Response to Pembrolizumab-Chemotherapy in BRAF Wild-Type Thyroid Cancer
A case of BRAF V600E wild-type, PD-L1-high anaplastic thyroid cancer that progressed on tyrosine kinase inhibitor therapy achieved a near-complete response lasting over 30 months on pembrolizumab combined with nab-paclitaxel and carboplatin.