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T Cells
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Why Cancer Risk Rises So Sharply With Age
Cancer risk climbs steeply with age. This article explains the overlapping biology, from mutation buildup and immune decline to chronic inflammation, that helps account for the pattern.
How the Immune System Spots Cancer Cells, and Why It Sometimes Misses Them
Explore how T cells and NK cells detect cancer cells, why some tumors evade immune attack, and how these discoveries led to checkpoint inhibitors and CAR-T therapy.
Why Lung Cancer Isn't One Disease, and What That Means for Treatment
Lung cancer kills more people worldwide than any other cancer, but it is not a single disease. Its causes, genetic drivers, and treatment options differ enormously from one tumor to the next.
SMARCA4-Deficient NSCLC with Rare Sigmoid Colon and Adrenal Metastases: A Case Report
A 59-year-old man with SMARCA4-deficient non-small cell lung cancer developed rare sigmoid colon and adrenal gland metastases, later responding favorably to an adjusted chemo-immunotherapy regimen.
CD19 CAR-T Therapy Produces Durable Remission in TP53-Mutated, Triple-Refractory Burkitt Lymphoma
A 16-year-old male with TP53-mutated Burkitt lymphoma, initially misdiagnosed and refractory to three chemotherapy regimens, achieved complete metabolic response and remains in remission 30 months after CD19-directed CAR-T cell therapy (axicabtagene ciloleucel).
Durable Near-Complete Response to Pembrolizumab-Chemotherapy in BRAF Wild-Type Thyroid Cancer
A case of BRAF V600E wild-type, PD-L1-high anaplastic thyroid cancer that progressed on tyrosine kinase inhibitor therapy achieved a near-complete response lasting over 30 months on pembrolizumab combined with nab-paclitaxel and carboplatin.